CRISPR-MEDIATED RAPID ARMING OF POXVIRUS VECTORS ENABLES FACILE GENERATION OF THE NOVEL IMMUNOTHERAPEUTIC STINGPOX

CRISPR-mediated rapid arming of poxvirus vectors enables facile generation of the novel immunotherapeutic STINGPOX

Poxvirus vectors represent versatile modalities for engineering novel vaccines and cancer immunotherapies.In addition to their oncolytic capacity and immunogenic influence, they can be Front Closure Bras readily engineered to express multiple large transgenes.However, the integration of multiple payloads into poxvirus genomes by traditional recombi

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Evaluation of Serodiagnostic Assays for Mycobacterium bovis Infection in Elk, White-Tailed Deer, and Reindeer in the United States

In 2011, the United States Department of Agriculture conducted a project in which elk (Cervus elaphus spp.), white-tailed deer (WTD) (Odocoileus virginianus), and reindeer (Rangifer tarandus) were evaluated by the single cervical tuberculin test (SCT), comparative cervical tuberculin test (CCT), and serologic tests.The rapid antibody detection test

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Glutamate Transporters GltS, GltP and GltI Are Involved in Escherichia coli Tolerance In Vitro and Pathogenicity in Mouse Urinary Tract Infections

To verify the roles of GltS, GltP, and GltI in E.coli tolerance and pathogenicity, we quantified and compared the relative abundance of gltS, gltP, and gltI in log-phase and stationary-phase E.coli and constructed their knockout mutant strains in E.coli BW25113 and uropathogenic E.coli (UPEC) separately, followed by analysis of their abilities to t

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